12. Eleanor Roosevelt
October 11, 1884 – November 7, 1962, was an American politician, diplomat, and activist. She was the longest-serving First Lady of the United States, holding the post from March 1933 to April 1945 during her husband President Franklin D. Roosevelt's four terms in office, and served as United States Delegate to the United Nations General Assembly from 1945 to 1952. President Harry S. Truman later called her the "First Lady of the World" in tribute to her human rights achievements.
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